We summarized the molecular mechanisms by which H19 regulates apoptosis and autophagy in the pathogenesis of cancers via its regulatory function in several oncogenic signaling pathways, such as the PI3K/Akt and canonical Wnt/β-catenin pathways, and through the H19/miR-675 axis (see Tables 1 and 2). Here, AKT1 is linked to cancer.