To understand the role of STAT3 in SMARCB1-deficient BLCA progression, we generated  KD of STAT3 using shRNA in T24 BLCA cells using  both the control and SMARCB1 KO (using clone C16) (Supplementary Fig. 11A; Fig. 4A). This evidence concerns the gene SMARCB1 and bladder transitional cell carcinoma.