Furthermore, GSEA analysis of the TCGA-BLCA cohort demonstrated significant enrichment of the IL6/JAK/STAT3 signaling pathway in tumors harboring either deep or shallow SMARCB1 deletions compared with SMARCB1 diploid tumors (Supplementary Fig. 2D; Supplementary Data 4). This evidence concerns the gene STAT3 and bladder transitional cell carcinoma.