NRGN and Alzheimer disease: Ng is a postsynaptic protein that is important for maintaining synaptic plasticity and regulating calcium ion influxes, while SNAP25 is a presynaptic protein that plays a crucial role in synaptic vesicle fusion and neurotransmitter release, and both these proteins have been shown to play a key role in AD disease pathophysiology, although they may be less clinically relevant for FTD [10, 45–48].