NPTX2 and Alzheimer disease: In an attempt to explore the synaptic pathology in FTD and AD, we recently performed a pilot study where we found that concentrations of CSF synaptic biomarkers synaptosomal-associated protein 25 (SNAP25) and neurogranin (Ng) were elevated in FTD compared with controls, while those of neuronal pentraxin 2 (NPTX2) were lower than in controls, suggesting these could be valuable biomarkers for FTD [15].