Finally, age, DM on insulin, absolute BMI (kg/m2), preoperative hospital stay ˃ 24 h, PAD, mediastinal re-exploration, BIMA harvesting, AKI and blood transfusions, application of fibrin sealant for sternal osteoporotic bleeding, postoperative delirium and pleural effusion requiring intervention, rounded the set of 12 independent predictors for “Extended” model (Table 3 and Supplementary Tables 3 - Additional File, Fig. 2). The gene discussed is INS; the disease is peripheral arterial disease.