APPL2 and obesity due to melanocortin 4 receptor deficiency: Other noteworthy genes in our candidate list were APPL2, an adiponectin receptor associated with overweight and obesity in a Chinese population [63], DOCK5, a susceptibility gene for severe obesity [64], and SLC30A8, a zinc efflux transporter implicated in type 2 diabetes and obesity in Asians [65].