LRP5 and Coats disease: OPPG is caused by biallelic variants in the gene encoding low-density lipoprotein receptor-related protein 5 (LRP5) [13], which often presents with vitreoretinal degeneration such as microphthalmia, phthisis bulbi, retinal detachments, persistent fetal vasculature, congenital retinal folds, exudative retinopathy, cataracts, and retinal calcifications.