OPPG is caused by biallelic variants in the gene encoding low-density lipoprotein receptor-related protein 5 (LRP5) [13], which often presents with vitreoretinal degeneration such as microphthalmia, phthisis bulbi, retinal detachments, persistent fetal vasculature, congenital retinal folds, exudative retinopathy, cataracts, and retinal calcifications. This evidence concerns the gene LRP5 and vitreoretinal degeneration.