To mitigate potential influences, we used AAV-mediated sclera THBS1 knockout instead of THBS1 global knockout mice, as THBS1 global knockout mice develop severe dry eye, akin to autoimmune disease Sjogren’s syndrome, which may not be suitable for studying myopia models (Turpie et al. 2009). The gene discussed is THBS1; the disease is Keratoconjunctivitis sicca.