The p.R90W variant has been shown to severely weaken CRX binding to target CREs and is reported to cause mild late-onset CoRD or LCA, depending on zygosity (Swaroop et al. 1999; Hull et al. 2014; Tran et al. 2014; Fujinami-Yokokawa et al. 2020; Zheng et al. 2023). The gene discussed is CRX; the disease is Leber congenital amaurosis.