Variants in CRX (OMIM: 602225) have been shown to cause several inherited retinal diseases, including retinitis pigmentosa (RP), cone-rod dystrophy (CoRD), and Leber congenital amaurosis (LCA) (Evans et al. 1994; Swain et al. 1997; Sohocki et al. 1998; Swaroop et al. 1999; Rivolta et al. 2001; Perrault et al. 2003; Ziviello et al. 2005; Nichols et al. 2010; Huang et al. 2012; Koyanagi et al. 2019; Fujinami-Yokokawa et al. 2020; Ng et al. 2020). Here, CRX is linked to Leber congenital amaurosis.