In a study most similar to ours, 11-week-old Pet-ChR-YFP mice (which express YFP exclusively in 5-HT neurons) were treated once daily with 18 mg/kg fluoxetine via drinking water for 6 weeks starting a week after an endothelin-1–induced stroke in the medial prefrontal cortex (Zahrai et al., 2020). This evidence concerns the gene EDN1 and Stroke.