The associations of dicarbonyls with the two inflammation markers may have been mediated at least in part by the strongly associated GFR since the latter is known to correlate with both.39, 40, 41 Indeed, ferritin and CRP were not selected by RDA, and when we conditioned their association analyses on GFR, waist-to-hip-ratio, GGT, and hypertension, both lost their significance (Supplementary Table S5). The gene discussed is CRP; the disease is Hypertension.