Besides elevating the LC3-II/LC3-I ratio, ATG5 and Beclin-1 levels and decreasing P62 level, the ANI/NEO combination decreased the expression of several inflammatory cytokines (INF-γ, TNF-α, IL-6, and IL-22) in colon tissue from mice with DSS-induced colitis. The gene discussed is IL22; the disease is colitis.