Peng et al. used IHC and flow cytometry to investigate the relationship between HMGB1 expression, T cell infiltration, and prognosis in 72 patients with resected stage IIIB colorectal carcinoma who received 6 months of adjuvant 5-fluorouracil (5-FU)-based chemotherapy [27]. The gene discussed is HMGB1; the disease is colorectal carcinoma.