MAPT and Alzheimer disease: Nevertheless, within the prefrontal cortex, a region which does not demonstrate robust age-related NFT tau pathology and is not burdened with NFTs until late into the Braak NFT staging criteria (Braak V–VI), the modest pre-tangle tau pathology generated in this region may be largely dependent on an intracellular Aβ-mediated mechanism within non-AD controls.