In line with the revised amyloid cascade hypothesis [27], a range of experimental models demonstrate that soluble pathological species of both tau and Aβ exert toxic influence within the brain, evident in rodent in vivo injection models [9, 38, 44, 55], familial AD (FAD) [5, 14, 65] and tauopathy [6, 37, 40] mouse models and cell culture approaches [15, 34]. Here, MAPT is linked to tauopathy.