Moreover, the Fe2+ levels and intracellular lipid ROS levels in mouse tumor tissues showed a marked elevation, while the numbers of FOXP3+CD25+ and CD8+ Treg cells in tumors were reduced, which revealed that LINC00942 inhibits ferroptosis and induces immunosuppression (Fig. 6E–H; p < 0.001, n = 5). This evidence concerns the gene CD8A and neoplasm.