CTLA4 and hepatocellular carcinoma: Moreover, LINC00942 knockdown induced a significant reduction in the expression levels of FOXP3/CD25, CTLA4, TNFRSF4, and TIGIT in CD4+ T cells after coincubation with transfected HCC cells, and this effect was reversed after SLC7A11 overexpression (Fig. 3B–E; p < 0.01, p < 0.001, n = 3).