In the analysis of baseline data of patients, the development of coagulopathy caused by CPZ was related to APACHE II score (p = 0.063), vitamin K1 prevention (p < 0.001), concurrent liver dysfunction (p < 0.001), Nutric score (p = 0.052), combined use of tigecycline (p = 0.041), gabapentin mesylate (p = 0.071), IL-6 level (p = 0.027), CRP level (p = 0.09), and creatinine clearance rate (CLcr) (p = 0.093). The gene discussed is IL6; the disease is Decreased liver function.