Briefly, TMZ‐resistant U87MG cells derived from the “Resistant Cancer Cell Line (RCCL) collection” and generated by chronic exposure to the drug (from now on referred to as U87MGRes),[21] were transfected with siRNA pools targeting each of the 709 human protein kinase and kinase‐related genes (Day 1) and treated with a sublethal dose of TMZ or DMSO (Day 2). Here, WEE1 is linked to cancer.