EPO and triple-A syndrome: SIRT1 belongs to a family of nicotinamide adenine dinucleotide (NAD+)‐dependent deacetylases with extraordinary abilities to prevent diseases and even reverse the aging process.[27] Highly expressed SIRT1 has been proven to protect vessels from VSMC senescence and AAA.[4] By Immunofluorescent analysis, we found SIRT1 expression was significantly down‐regulated in VSMCs of EPO‐induced AAA compared with that in the vehicle group, which were up‐regulated in VSMCs of EPO + medium‐dose formoterol group relative to EPO group (Figure 5E,F).