For instance, increased telomere attrition and DNA double‐strand breaks were found in cultured VSMCs from human AAA.[8] Age‐related reduction of Sirtuin 1 (SIRT1) in VSMCs accelerates vascular aging and promotes the formation and rupture of AAA.[4] These findings highlight the importance of VSMC senescence in AAA. Here, SIRT1 is linked to triple-A syndrome.