GNAS and triple-A syndrome: As an example, our previous study demonstrated that smooth muscle‐specific knockout of the α subunit of the heterotrimeric G stimulatory protein (Gsα) reduced cAMP production and exaggerated AAA in mice.[12] Inhibition of both cAMP production and SIRT1 activation promoted VSMC senescence and aggravated the development of AAA.[13] However, the effect of formoterol on AAA has not been reported.