In addition, the serum and tumor homogenate concentrations of proinflammatory cytokines, including IFN‐γ, TNF‐α, IL‐6 and IL‐1β, increased significantly in the B16F10 cell–rechallenged mice of the HM‐NPs group (Figure 5h–j; Figure S18, Supporting Information). This evidence concerns the gene TNF and neoplasm.