Regions within keloid tissues mirroring the tissue architecture and stiffness attributes of normal skin tissues are termed “Soft,” whereas those featuring thick collagen bundles and heightened stiffness are designated as “Stiff.” Intriguingly, fibroblasts near thick collagen bundles in stiff regions exhibited higher α‐smooth muscle actin (α‐SMA) expression compared to those in soft regions (Figure 1d; Figure S1a–c, Supporting Information). The gene discussed is ACTA1; the disease is keloid.