TP53 and cancer: Biologically, the downregulation of CDC25C induces cell cycle arrest in the G2/M phase in response to DNA damage via p53‐mediated signal transduction, and its abnormal expression is associated with cancer initiation, development, metastasis, occurrence, and poor prognosis.[41] What's more, the negative perturbation of CCNE2 led to an increase in the barrier height of the G2‐M phase with a higher chance of arrest in this phase, while the positive perturbation of CCNE2 led to a deeper basin of the G1‐S phase with a higher chance of arrest in this phase (Figure S10, Supporting Information).