For example, adult gliomas are often driven by IDH1 or IDH2 mutations (Cancer Genome Atlas Research Network et al., 2015), while subsets of low-grade pediatric gliomas are driven by rearrangements in the transcription factor-encoding proto-oncogenes MYB or MYB like 1 (MYBL1) (Qaddoumi et al., 2016). Here, IDH2 is linked to central nervous system cancer.