Influential protein-protein interactions predicted by Leave-One-Edge Out (LOEO) analysishighlights key interactions between influential vertices with mega-hub proteins, along with several major-hub proteins previouslyimplicated in AD such as PRP8 (regulation of spliceosomes), ATRX (chromatin remodeling), ELYS (nuclear pore assembly), SPB1 (rRNAmethylation), and PAIRB (proteasomal degradation and apoptosis) among the top 25 influential protein-protein interactions. The gene discussed is ATRX; the disease is Alzheimer disease.