MAPT and Alzheimer disease: In the case of AD, protein aggregation isthought to be initiated by "seed" proteins, amyloid beta (Aβ) and hyper phosphorylated tau (hP-tau) [1].As these oligomers expand, they recruit other proteins that transiently unfold or misfold, chiefly through hydrophobic interactions withamyloid or neurofibrillary tangles (NFTs) [2, 3].