Also, RNAi knockdowns of genes encoding EIF3A, SRSF6, RBBP6, ASPM, RFC1, and RNPS1 improvedchemotaxis significantly in C. elegans strain CL2355, an AD model expressing human Aβ1-42 in all neurons leading to age-progressiveor thermal-induction-dependent loss of normal chemo-attraction to n-butanol. The gene discussed is RFC1; the disease is Alzheimer disease.