Of 77 major-hub proteins, 12 were among the top 25 influentialproteins: MAP1A, RFC1, ZN638, NIPBL, RNPS1, SAFB1, TOP1, BAZ1A, KMT2A, HNRPR, BCLF1 and TRIPC, all of which were previously implicatedin AD [11,12,13,14]. The gene discussed is HNRNPR; the disease is Alzheimer disease.