HIF1A and cancer: Many reports link high tumour HIF-1α expression with a poor prognosis including meta-analyses of studies in brain (n=1,422) (78), breast [BCa] (n=6,201) (79), digestive system (n=5,964) (80), hepatocellular [HCC] (n=3,570) (81), and oral cavity (n=1,471) (82) cancers.