After that, the new DSP model was also validated in pan-cancer cohorts from PCAWG and ICGC, glioma from CGGA, LUAD from GEO (GSE30219, GSE31210, GSE37745, GSE50081), and UVM from GEO (GSE22138) with significant p-value (Figures 8A–F). This evidence concerns the gene DSP and central nervous system cancer.