In TCGA, the 14 validated disulfidptosis-related genes (DRGs) - ACTB, TLN1, CAPZB, STN, FLNB, IQGAP1, ACTN4, MYL6, FLNA, MYH9, MYH10, PDLIM1, CD2AP, and INF2 - were generally expressed in all 33 types of cancer (Figure 1A). Here, ACTN4 is linked to cancer.