Type I IFNs interfere with viral infection through the induction of a vast repertoire of ISGs via the Jak/STAT pathway, some of the ISGs exerting a direct antiviral activity such as mx, viperin/vig1, and isg15 (50), the expression of which can be simulated during IHNV infection (34). The gene discussed is SOAT1; the disease is viral infectious disease.