Additionally, these vaccines may cause false-positive reactions on immune-based tests for Mycobacterium bovis (16, 18), just as there is evidence that co-infections with M. bovis and paratuberculosis may reduce the sensitivity of the tuberculin skin test and the IFN-γ release assay used for detecting bovine tuberculosis (19, 20). Here, IFNG is linked to Tuberculosis, Bovine.