At 4-6 weeks of age, the progeny was subcutaneously injected with TAM to activate Cre recombinase and generate A20FLAppNL-G-F mice and A20Cx3Cr1-KOAppNL-G-F mice which do (A20FL) or do not (A20CxcCr1-KO) express A20 in microglia in an amyloid model of AD pathology. This evidence concerns the gene TNFAIP3 and Alzheimer disease.