TNF and Arthritis: Leonurine can inhibit the expression of TAZ, reduce the levels of inflammatory factors IL-17, IL-6, IL-1β, and TNF-α, increase the expression of anti-inflammatory cytokine IL-10, increase the proportion of Treg cells, decrease the proportion of Th17 cells, reverse the Treg/Th17 imbalance induced by TAZ, and alleviate arthritis inflammation (215).