IL-10 is an important anti-inflammatory and immunosuppressive cytokine, reduces the expression of serum IL-6 by upregulating suppressor of cytokine signalling 1 (SOCS1), which not only leads to a decrease in anti-type II collagen antibody levels but also directly acts on various immune cells and inhibits T cells from producing pro-inflammatory cytokines, thus reducing the severity of arthritis and playing a key protective role in RA (88). This evidence concerns the gene IL6 and rheumatoid arthritis.