TNF and rheumatoid arthritis: XX constructed a CIA mouse model, and found that PDX obviously delayed RA progression in CIA, upregulated the mRNA level of Tregs cells and Treg characteristic transcription factor FOXP3 and the expression of anti-inflammatory cytokines IL10 and TGF-β, but downregulated the mRNA level of Th17 cells, Th17 characteristic transcription factor ROR-γ t and the expression of pro-inflammatory cytokines IL-1β, IL-18, IL-6, TNF-α, and IL-17A.