Interestingly, the gene expression profile related to responses to virus of Gzma-high effector CD8+ T cells was temporally reversed throughout viral infection, and the GO (Supplementary Figure S4F) and GSEA (Figure 5E) analyses showed that Gzma-high effector-like CD8+ T cells had significantly lower gene enrichment in response to viral infection on 4 dpi (Figure 5E) but higher enrichment on 8 dpi during chronic infection than during acute infection (Figures 5F, S4F). This evidence concerns the gene CD8A and viral infectious disease.