In this study, to explore the dynamics and heterogeneity of immune cells in acute and chronic viral infections at different times, we analyzed CD45+ immune cells from mouse lymph nodes using high-throughput scRNA-seq, single-cell B-cell receptor sequencing (scBCR-seq) and single-cell T-cell receptor sequencing (scTCR-seq). The gene discussed is PTPRC; the disease is viral infectious disease.