Our recent findings confirm the insulin secretagogue propertiesof the C16:1(9Z) isomer and show that this biologicalfunction depends on the activation of GPR40, GPR55, GPR119, and GPR120receptors.11 All these GPCRs are consideredpotential targets for the pharmacological management of diabetes.12−15 The C16:1(9E) isomer also augments insulin releasefrom pancreatic β cells but signals not only through Gq as observed with the endogenous lipid ligands, including C16:1(9Z), but also through Gs. The gene discussed is INS; the disease is diabetes mellitus.