INS and diabetes mellitus: Studies on lysophosphatidylcholines(LPCs) indicate their important role in the metabolism of glucoseand lipids, broadening our knowledge of some disease mechanisms suchas diabetes.1,2 LPCs, apart from their nonspecificmembrane interactions, act as ligands of G protein-coupled receptors(GPCRs) GPR553 and GPR1191,2,4 causing a mobilization of intracellularcalcium, cyclic AMP (cAMP) synthesis, and an increase in insulin secretion.The structural geometry of LPC is a critical factor for the finalactivity and it depends mainly on the saturation and length of theacyl chain.5