Independent clinical prognostic variables s associated with OS and detected at least two studies were: albumin level (5/12), Child-Pugh grade (4/12), alpha-fetoprotein level (4/12), tumor size (4/12), tumor number (4/12), the Tumor, Node, Metastasis stage (2/12), BCLC stage (2/12), mRECIST (2/12), bilirubin level (2/12) and portal vein thrombosis (2/12). This evidence concerns the gene AFP and Portal vein thrombosis.