FERMT2 and neoplasm: In addition to data at the transcriptional level, IHC staining confirmed a decrease in protein levels of CD163 and CD206 (representing tumor-infiltrating M2 macrophages) with increased level of FERMT2 proteins (Figures 5(d) and 5(e); CD163, R = 0.543, P < 0.001; CD206, R = 0.500, P = 0.001).