In this review, we have attempted to approach ASD from the perspective of dysfunction in AMPAr-mediated neural circuits, with a focus on cerebro-cerebellar connectivity and the synaptic dysfunction emerging in two prototypical synaptopathies, Shank3/Phelan McDermid Syndrome and SYNGAP1-DEE. This evidence concerns the gene SHANK3 and Phelan-McDermid syndrome.