Simultaneously, inconsistent results were also observed in the association between IL-6 and IBS, in which the IVW (OR: 1.137, P: 6.923E-16) and weighted median method (OR: 1.069, P: 0.009) showed that increasing levels of IL-6 had a causal effect on IBS, whereas, the MR-Egger method showed that IL-6 had a protective effect on IBS (OR:0.883, P =0.023). Here, IL6 is linked to irritable bowel syndrome.