In a carefully controlled cohort study of tubal ligation, the hazard ratio for Type I endometrioid uterine cancer was 0.78, but the hazard ratio was strikingly 0.25 for Type II, typically p53-mutant uterine serous carcinoma, indicating surprisingly low incidence of Type II tumors following tubal ligation [64]. Here, TP53 is linked to endometrial serous adenocarcinoma.