Immunoprecipitation studies in HA-CHMP5-expressing T-ALL cells showed p300 association with CHMP5 in nuclear lysates from CUTLL1 T-ALL cells (Figure S4B) and in cell-free assays, recombinant CHMP5 immunoprecipitated with p300 (Figure 4D), consistent with a direct binding between both proteins. The gene discussed is EP300; the disease is acute lymphoblastic leukemia.