NOTCH1-driven T-ALL cells like the CUTLL1 human T-ALL cell line are highly resistant to single or combination treatment with γ-secretase inhibitors (GSI) and glucocorticoids including dexamethasone (Dex) as ICN1-induced program represses expression of the glucocorticoid receptor NR3C161,62. The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.