Notably, DEGs in ICN1-driven murine T-ALL cells and human NOTCH1-driven T-ALL cells lacking CHMP5 included multiple overlapping genes and pathways highlighted by MYC (and MYC target genes) (Figures S6H and S6I) which is induced by ICN1 by a BRD4-dependent mechanism17–19. Here, MYC is linked to acute lymphoblastic leukemia.