BRD4 and acute lymphoblastic leukemia: Importantly, consistent with their downregulated expression (Figure S3G), we found drastically diminished H3K27ac density across these key T-ALL genes, with significant loss of H3K27ac and BRD4 at both typical enhancers and super-enhancers in CHMP5-deficient T-ALL cells (Figures 3M and S3H).