CHMP5 and acute lymphoblastic leukemia: Control and CHMP5-deficient T-ALL cells showed comparable MYC protein stability in cycloheximide (CHX) chase assays and proteasome inhibition by MG132 failed to restore its MYC levels (Figures S1E to S1G), implying that CHMP5 likely controlled MYC expression at the level of transcription, in contrast to its post-translational activity in thymocytes and osteoclasts29,30.