CHMP5 and acute lymphoblastic leukemia: Thus, that CHMP5 deficiency resulted in the severe depletion of all CD34+ cells in primary murine T-ALL, including loss of the LIC-enriched CD34+MYC-GFPhi fraction, indicated that failure of CHMP5-deficient progenitors to support ICN1-driven T-ALL was likely due to impaired generation of LICs.