CHMP5 and acute lymphoblastic leukemia: Specifically, in CHMP5-sufficient T-ALL cells, p300-catalyzed H3K27ac recruits initial BRD4 binding via its bromodomain and in turn, chromatin-bound BRD4 recruits additional p300 proteins, which catalyzes further H3K27ac reactions and enrichment at enhancers and super enhancers.