Therefore, to gain insight into how CHMP5 promoted transcription of BRD4-dependent T-ALL genes like MYC, we wondered if it instead controlled BRD4 binding at distal enhancers defined by hyperacetylated histone modifications, including H3 lysine 27 acetylation (H3K27ac)45,46. Here, BRD4 is linked to acute lymphoblastic leukemia.