CD4 and acute lymphoblastic leukemia: Furthermore, while these CD45.2+NGFR+ cells were phenotypically all CD4+CD8+ in WT T-ALL animals, the few KO CD45.2+NGFR+ cells had reduced frequencies of CD4+CD8+ cells and instead were also comprised of CD4−CD8+ and CD4−CD8− fraction (Figure S6F), implying impaired ICN1-induced T-ALL lineage commitment.