In line with their comparable expression in normal T-cells and T-ALL cells (Figures 5B, S5B and S5C), expression of VPS4A and CHMP1A did not correlate with T-ALL patient survival (Figures S5D and S5E), supporting the unique role for CHMP5 in T-ALL pathogenesis. Here, CHMP1A is linked to acute lymphoblastic leukemia.