Intriguingly, CHMP5 is dispensable for normal CD4+CD8+ thymocyte generation30 (that lack MYC) but required for MYC+CD4+CD8+ T-ALL cells, implying that oncogenic ICN1 activity created a dependency on CHMP5 as part of the transcriptional rewiring required for T-ALL initiation. Here, CD4 is linked to acute lymphoblastic leukemia.