Reflecting that the CHMP5-BRD4-p300 axis is a general requirement in T-ALL cells, loss of CHMP5 also synergized with AraC in both activated NOTCH1-driven (CUTLL1 and SUPT1) and NOTCH1-independent (LOUCY) T-ALL cells (Figures 5E and 5F). Here, EP300 is linked to acute lymphoblastic leukemia.