In line with this, we found that the majority (~71%) of DEGs in CHMP5-deficient T-CUTLL1 T-ALL cells have BRD4 bound promoters (GSE51800)38 and were genes that mediated the topmost perturbed pathways in these CHMP5-deficient T-ALL cells (Figures 2J and 2K). Here, BRD4 is linked to acute lymphoblastic leukemia.