Chen (103) employed weighted gene co-expression network analysis to identify genes associated with HCC (BAK1 (encoding BCL2 antagonist/killer 1), SPP1 (encoding secreted phosphoprotein 1), BSG [encoding basigin (Ok blood group)], PBK (encoding PDZ binding kinase), and DAP3) and establish a predictive risk model. The gene discussed is SPP1; the disease is hepatocellular carcinoma.