From the analysis, DAP3 expression was inversely correlated with most of the angiogenesis biomarkers, such as vascular endothelial growth factor C (VEGFC), angiopoietin 2 (ANGPT2), platelet and endothelial cell adhesion molecule 1 (PECAM1), sphingosine-1-phosphate receptor 1 (S1PR1), and S1PR2, which indicated that high DAP3 expression might actively suppress the angiogenesis in colon tumors (94). Here, S1PR1 is linked to colonic neoplasm.