Recently, Jia and his coworkers (20) determined the expression levels of Leucine-rich G-protein coupled receptor 5 (LGR5), an important downstream molecule of β-catenin signaling (21, 22), in gastric cancer cell lines (MGC803 and HGC27) with low DAP3 expression and found that LGR5 expression was upregulated in these DAP3-deficient gastric cancer cells, while downregulation of LGR5 re-sensitized DAP3-deficient gastric cancer cells to 5-FU and oxaliplatin. The gene discussed is LGR5; the disease is gastric cancer.