Neoplastic cell invasion and tumor growth were reduced following the pharmacological inhibition of IL-11/STAT3 in human tumor cell xenografts and mouse gastrointestinal cancer models (63).And IL-11 can alleviate cardiac fibrosis after myocardial infarction (64) and protects hepatocytes in liver ischemia through the activation of the IL-11/gp130/STAT3 signaling pathway (65). This evidence concerns the gene IL11 and neoplasm.