MAPT and early-onset autosomal dominant Alzheimer disease: It is important to note that growing evidence from genome-wide association studies (GWAS) has shown that a variety of AD risk genes are involved in inflammation signaling that influences the development and course of the disease (Marioni et al., 2018; Jansen et al., 2019), supporting the notion that sustained inflammation caused by abnormally folded Aβ and tau proteins accumulation plays a crucial role in the pathophysiology of Alzheimer’s disease.