BCHE and Alzheimer disease: This notion is supported by a previous study that demonstrated how treatment with donepezil, a cholinesterase inhibitor used to effectively treat AD by enhancing cholinergic neurotransmission (Birks and Harvey, 2018), led to changes in rCBF in the PCC, along with changes in MMSE and AD assessment scale-cognitive scale scores (Iizuka and Kameyama, 2017).