These new findings are consistent with previous reports demonstrating that MEK1/2-ERK1/2 pathway inhibition reduces airway epithelial cell, including CF epithelial cell, production of IL-8 (Bhattacharyya et al., 2011; Cormet-Boyaka et al., 2012), and that inhibition of the MEK1/2-ERK1/2 pathway can prevent airway epithelial cell CFTR degradation (Xu et al., 2015; Wellmerling et al., 2022). Here, MAP2K1 is linked to cystic fibrosis.