3‐(4‐Chlorophenyl)‐adamantane‐1‐carboxylic acid (pyridin‐4‐ylmethyl) amide, named ABC294640, is a selective inhibitor of SPHK2 that can decrease S1P synthesis and rescue Ang II‐induced hypertension in mice.23, 24. Here, SPHK2 is linked to Hypertension.