Interleukin-12 (IL-12) and Interleukin-18 (IL-18), are a class of cytokines associated with the suppression of angiogenesis (29), production of interferon-gamma (20), induction of apoptosis in cancer cells (30), and the activation of cytotoxic T cells and natural killer cells (20, 31). This evidence concerns the gene IL18 and cancer.