PEMT and digestive system cancer: None of the other variables, including age (<65 compared with ≥65 y; P-interaction = 0.165), sex (P-interaction = 0.313), center (Lianyungang compared with Rongcheng; P-interaction = 0.073), current smoking status (ever compared with never; P-interaction = 0.370), alcohol drinking status (ever compared with never; P-interaction = 0.626), choline (<2.2 compared with ≥2.2 μg/mL; P-interaction = 0.751), and betaine (<6.1 compared with ≥6.1 μg/mL; P-interaction = 0.322), significantly modified the association between PEMT rs7946 and digestive system cancer risk.