AGO2 and canker sore: On the contrary, the levels of pS417‐AGO2 were reduced in A549 (Figure 3L), H1975 (Figure S3G, Supporting Information) and H1299 cells (Figure S3H, Supporting Information) by Amlexanox, which is a specific inhibitor of TBK1[47] and used to treat recurrent aphthous ulcers.[48] Taken together, we proved TBK1 specifically phosphorylated AGO2 at S417 in vitro and in vivo.