Among the DEGs, five downregulated genes (TUBB2B (logFC: −4.76441, p.value: 6.36E‐15), MAPK7 (logFC: −2.10173, p.value: 1.48E‐12), TUBAL3 (logFC: −2.04648, p.value: 2.98E‐09), ADCY1 (logFC: −6.0183, p.value: 3.52E‐15) and MAP2K5 (logFC: −5.30811, p.value: 1.10E‐13)), and two upregulated genes, TUBA3D (logFC: 2.30119, p.value: 2.44E‐12) and TUBB4A (logFC: 3.361404, p.value: 7.33E‐15) were found to be involved in gap junction pathways associated with cisplatin‐resistant NSCLC cell lines. Here, TUBA3D is linked to non-small cell lung carcinoma.