We found a highly significant negative correlation between individual tumor scores in these bulk tumor tissue along a MYC–PRC axis, with PDS1 tumors displaying high-MYC–low-PRC target expression and PDS3 tumor displaying low-MYC–high-PRC target expression, and PDS2 tumors being intermediate (Fig. 5c and Extended Data Fig. 5g). The gene discussed is MYC; the disease is neoplasm.