Elevated expression of MIR4435-2HG is related to poor prognosis and aggressive tumor behavior of various cancers including NSCLC, which might attribute to its ceRNA activity via miRNA competition and its regulatory impact in a variety of signaling pathways, such as TGF-β and β-catenin pathways (Zhong et al. 2022). Here, TGFB1 is linked to cancer.