TGFB1 and Myocardial fibrosis: In mice with overexpression of TGF-β, the level of collagen in the left ventricular tissue and the protein expressions of TIMP-1,2,4 are enhanced, and the levels of active MMPs responsible for collagen catabolism are inhibited, suggesting the link between TGF-β/TIMPs and myocardial fibrosis [70].