In addition, they were intimately involved in cytokine-cytokine receptor interaction, viral protein interaction with cytokine and cytokine receptor, chemokine signaling pathway, phagosome, rheumatoid arthritis, endocytosis, neutrophil extracellular trap formation, and PI3K-Akt signaling pathway, all of which contributed to regulating the host immunity. Here, AKT1 is linked to rheumatoid arthritis.