In addition, they were intimately involved in cytokine-cytokine receptor interaction, viral protein interaction with cytokine and cytokine receptor, chemokine signaling pathway, phagosome, rheumatoid arthritis, rndocytosis, neutrophil extracellular trap formation, and PI3K-Akt signaling pathway, all of which contributed to regulating the host immunity (Fig. 6b and Supplementary Table 5). The gene discussed is AKT1; the disease is rheumatoid arthritis.